Abstract

Objective To analyze serum soluble suppression of tumorigenicity 2 (sST2) levels and their clinical significance in the acute attack of bronchial asthma (asthma). Methods Selected 76 patients with acute exacerbation of asthma in Yazhou District Yacheng Health Center from May 2016 to April 2018 were included in the study group.In addition, 60 healthy residents who were examined in Yazhou District Yacheng Health Center during the same period were included in the control group.Serum sST2, related inflammatory factors [interleukin-6 (IL-6) and IL-10] and immunoglobulin E (IgE) levels were measured in two groups by enzyme-linked immunosorbent assay.Two sets of blood test results were analyzed to analyze the relationship between serum sST2 levels and the severity of the patient′s condition. Results Compared with the control group, serum sST2, IL-6 and IgE levels in the observation group were significantly increased, while serum IL-10 was significantly decreased, and the difference was statistically significant (P<0.05). The levels of serum sST2 and IL-6 levels gradually increased with the severity of asthma in acute exacerbation, and serum IL-10 levels gradually decreased with the severity of asthma in patients with acute exacerbation.The serum sST2, IL-6 and IL-10 levels in patients with severe asthma were significantly different from those in mild asthma and moderate asthma groups(P<0.05). Pearson correlation analysis showed that serum sST2 levels was positively correlated with IL-6 and IgE (P<0.05), but negatively correlated with IL-10 (P<0.05). Conclusions Soluble human matrix lysin 2 is highly expressed in the serum of patients with acute asthma attack, and its expression level is related to the severity of the disease.It is speculated that it may become an evaluation index of clinical asthma. Key words: Asthma, bronchial; Serum soluble suppression of tumorigenicity 2; Acute attack

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