Level of Interleukin-6 and Interleukin-1 1 β Associated Bacterial Burn Infections Patients in Al-Kindy Hospital

Abstract

Background : Burn infections was the most important caused mortality and morbidity in Iraqi hospitals , which caused by gram positive and negative bacteria. Material and methods collected 151 wound swab and serum from burn patients during the period from January – April 2019 in Al-Kindy Hospital (Baghdad ), all swab were inoculated on ( McConkey and blood) agar and incubated aerobically overnight at 370C ,and identified isolated of bacteria by Vitek system, also determinate the level of both interleukin -6 and interleukin -1 beta by Elisa. Results in current study showed male of burn patients (70.8% ) ore than female (29.2), as well as control group. Burn patients was more in age group (1-15)as percentage (31.8% ) ,followed by (15-30) years as ( 29.2%), but more bacterial isolated in age group (15-30) years as (36.2%), followed by (45? ) years as (25.5%),whilst low percentage (17.0 %) in age group (1-15), Single bacterial isolate (61.5%) more than Mixed bacterial isolate(38.5%), also results of current study showed Gram negative bacteria(74%) more isolated from burn infection than Gram positive bacteria(26%).More bacterial isolate as Single Bacterial isolate were Pseudomonas aeruginosa (923%), followed both Klebsiella pneumoniae and E.coli as (18.4 and 18.0 ) % respectively , whilst bacterial isolate as mixed Bacterial isolate were Pseudomonas aeruginosa + E.coli(4%) , increased level of Interleukin- 6 in sera of burn infected patients (1.3 ± 0.51) compare to healthy control (0.44 ± 0.20) (p 0.05 )for level of Interleukin-1B in sera of patients (0.70 ± 0.30) and healthy control (0.190 ± 0.019).conclusion Male of burn patients more than female also more bacterial isolated in age group (1530) years followed by (45? ) years , so single bacterial isolate more than Mixed bacterial isolate. and gram negative bacteria more isolated from burn infection than Gram positive bacteria. as well as more bacterial isolate as Single Bacterial isolate were Pseudomonas aeruginosa , followed both Klebsiella pneumoniae and E.coli, whilst bacterial isolate as mixed Bacterial isolate were Pseudomonas aeruginosa + E.coli , also increased level of Interleukin- 6 in sera of burn infected patients (p 0.05 ) for level of Interleukin-1B.