Interleukins levels associated with Chronic Otitis Media (CSOM)

Abstract

Background: Chronic Otitis Media (CSOM) is chronic inflammatory diseases of the middle ear, as a complication of acute otitis media, which may caused hearing loss. Objectives: To determine the level of interleukins 6 and 8 associated the Chronic Otitis Media (CSOM) in Iraqi patients. Patients and Methods The study group included 95 patients who suffering from Chronic Otitis Media (CSOM), that attended the kindy hospital, also control groups 30 matched healthy individuals who attended kindy hospital for only check up, both groups were exclude any infections or inflammation, during period July 2018 to February 2019. The ear swab samples were culturing on both (Blood agar and Mac Conkey agar) plates and incubated at 37C. Then identification of bacterial strains by Vitek system, determinate Serum levels of IL-6 and 8 by ELISA kits. Results: bacterial Chronic Suppurative Otitis Media was more in age group were groups (21-35) years as percentage (36%) followed by (36- 45) years as percentage (28%), also female (53.3%) more than male (46.6%), so most pathogenic bacteria isolates from ear infections was Pseudomonas aeruginosa. the mean concentration of Both interleukins ( IL-6 and 8) ± Standard division were 10.31± pg/ml ± 1.30; 30.722 pg/ml ± 11.652 respectively in CSOM compare to control. Conclusion: current study conclude more age group has bacterial Chronic Suppurative Otitis Media was (= 46) years as well as female more than male. So gram negative bacteria (GNB) were more isolated than gram positive bacteria (GPB) which isolated from otitis media. most pathogenic bacteria isolates from ear infections were Pseudomonas aeruginosa and Staph. aureus, Mean concentration of Both interleukins (IL-6 and 8) were increased in CSOM compare to control.