Abstract
Tumor necrosis factor (TNF) is a major cytokine which mediates endotoxin shock and causes multiple organ damage. Carrageenan (CAR), a sulfated polygalactose, is used as a macrophage blocker. We found that CAR pretreatment can enhance both lipopolysaccharide (LPS) induced TNF production and the rate of lethality in mice [1]. We postulated that inflammation plays a role in the mechanism of enhanced LPS-induced TNF production and lethality by CAR pretreatment because CAR is used not only as a macrophage blocker but also as an inflammatory agent. Recently it has been reported that leukotriene (LT) inhibitors suppress the LPS-induced TNF production and lethality in galactosamine-treated mice [2]. We therefore investigated the effect of 5-lipooxygenase inhibitor and LTC4D4 antagonist on LPS-induced TNF production and lethality in CAR-pretreated mice.
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