Abstract
Several recent data suggest that in severe injuries, such as a shock state, the gradual activation of Kupffer cells and the excessive release of destructive and immunosuppressive products from macrophages may contribute to the development of “multiple organ failure”. The effect of Kupffer cell phagocytosis blockade on the correlation between the tissue distribution of bacterial lipopolysaccharide (LPS), endotoxin sensitivity and LPS-induced tumor necrosis factor (TNF) production was investigated in in vivo experiments in mice. To depress the activity of the Kupffer cells, gadolinium chloride (GdCl 3) or carrageenan was used. The studies indicated the dissociation of the tissue localization of 51Cr-labeled endotoxin and endotoxin lethalithy. Both GdCl 3 and carrageenan depressed the Kupffer cell activity, but the endotoxin sensitivity was enhanced only by carrageenan treatment. However, there was a close correlation between the sensitivity to LPS and LPS-induced TNF production as measured in the serum, since LPS-induced TNF production was enhanced only by carrageenan treatment.
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