Abstract
Inflammatory peritoneal exudates from 11 patients with purulent peritonitis or non-perforative appendicitis were analyzed by gas chromatography mass spectrometry (GC-MS) for their content of 5S, 12R-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid (LTB 4) and its ω-oxidized catabolite, 5S,12R,20-triliydroxy-6,8,10,14-eicosatetraenoic acid (20-OH-LTB4). Eleven samples of peritoneal exudates were examined. LTB 4 and 20-OH-LTB 4 were demonstrated only in the samples from patients with purulent peritonitis. LTB4 was detected in 4 samples, and 20-OH-LTB 4 was detected in 6 samples by GC-MS with selected ion monitoring. In addition, a nearly full spectrum corresponding to that of synthetic 20-OH-LTB 4 was obtained with 3 samples. Neither LTB 4 nor 20-OH-LTB 4 were detected in samples from patients with non-perforative appendicitis. LTB 4 or 20-OH-LTB4 may be related to the pathophysiological mechanism of purulent inflammations.
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