Leukotriene antagonist montelukast sodium combined with seretide for senile asthma

Abstract

Objective To investigate the efficacy of leukotriene antagonist montelukast sodium combined with seretide in the treatment of senile asthma.Methods 62 elderly patients with asthma were randomly divided into two groups,and then received conventional treatment plus inhaled seretide of 250 μ g twice daily ( 31 patients,control group ) or plus the same seretide combined with leukotriene antagonist montelukast sodium of 10 mg per night ( 31 patients,study group ).The efficacy was compared between the two groups.Results After treatment,symptoms were markedly relieved and lung function was significantly improved in both groups ( 90.32％ vs.70.97％ for the total effectiveness rate ) symptom relief and improvement in lung function were more significant in the study group [FEV 1.0:(2.24 ± 0.41) Lvs.( 1.92 ± 0.27) L,FEV1.0％:(0.45 ± 0.11 ) vs.(0.37 ± 0.09),PEF:(4.55 ± 0.12) L/s vs.( 4.03 ± 0.27 ) L/s ; P ＜ 0.05].Conclusions Combination therapy with leukotriene antagonist montelukast sodium and seretide for senile asthma has a better efficacy and is worth being applied clinically. Key words: Leukotriene antagonist; Montelukast; Seretide; Asthma; Elderly patients