Curative efficacy of Montelukast combined with Seretide for the treatment of cough variant asthma and its effect on airway inflammation

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Objective To study the curative efficacy of Montelukast combined with Seretide for the treatment of cough variant asthma (CVA) and its effect on airway inflammation. Methods 70 patients of CVA, who received therapy from March 2015 to March 2016 in our hospital, were selected as research objects.According to random number table, those patients were divided into the observation group and the control group, with 35 patients in each group.The control group was treated with Seretide, while the observation group was treated with Montelukast combined with Seretide.The duration in which the symptom of the patients was improved after treatment, pulmonary ventilation function, proinflammatory cytokine levels, eosinophil (Eos), and fractional exhaled nitric oxide (FeNO) were compared. Results After treatment, the duration for symptom relief and disappearance of the observation group were shorter than that of the control group[(6.05±1.44)d vs(7.21±1.52)d, (7.63±1.75)d vs(8.74±1.58)d](P<0.05). The FEV1, FEV1/pred, FEV1/FVC and PEF/pred were significantly higher in the observation group than those in the control group(P<0.05). The level of interleukin(IL)-12 in the observation group was higher than that in the control group [(84.26±10.97) ng/L vs(68.13±9.82)ng/L](P<0.05). The tumor necrosis factor-α (TNF-α) and IL-6 were lower than those in the control group [(0.65±0.13) ng/L vs(0.94±0.16) ng/L, (14.11±3.78)ng/L vs(20.43±4.14)ng/L] (P<0.05). The Eos and FeNO in the observation group were lower than those in the control group [(2.61±1.75)% vs (5.34±2.03)%, ( 45.68±11.43) ppb vs (78.46±18.42) ppb] (P<0.05). Conclusion The treatment of cough variant asthma with the combination of Sulidide and montelukast can effectively improve patients with pulmonary ventilation function, and it shorted the treatment time, relieved airway inflammation and improved the patient's inflammatory response. Key words: Seretide; Montelukast; Cough variant asthma; Inflammation