Abstract
This paper documents a possible mechanism of the leucocyte adherence inhibition (LAI) test: After interaction with monocytes sensitized by a polyarthritic serum and a normal synovial extract, cultured T cells produced in the supernatant an activity able to modify the adhesiveness of polymorphs (PMN) to glass. After 90 min of contact with sensitized monocytes, T-cell supernatants induced the detachment of three times more PMN than did supernatants from T cells after a contact lasting only a few minutes. The 90-min supernatant caused a dramatic reduction of pseudopod extrusion at the PMN surface, as seen by scanning electron microscopy. The functional effect of the supernatant was able to enable 53% of PMN to engulf yeast particles compared to 30% of control cells. Therefore, it is suggested that the LAI test involves a sequential mechanism leading to the activation of PMN in such a manner that they lose their adherence to glass.
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