Leukemia its origin, types, risk factors and survivorship

Abstract

Leukemia cancer; Feline leukemia virus (FeLV); CAR-Natural Killer and CAR-macrophages; TPMT and NUDT15 genes; Thiopurines.Leukemia is a cancer of the body’s blood forming tissues such as bone marrow and the lymphatic system. It is most common cancer in the children but mostly occur in adults.The general symptoms in leukemia cancer are appetite and headaches, and red patches on the skin of patients.The hematopoietic stem cell help to regenerate the healthy and leukemia free cells of white blood cells in bone marrow of patients and slowly-slowly cure the leukemia patients. Feline leukemia virus (FeLV) is retrovirus globally impact on the health and cause tumor and bone marrow disorder and immune suppression. The CAR-Natural Killer and CAR-macrophages were introduced as a complement or alternative to CAR-T cells therapy for solid tumor. The thiopurines interfere with the synthesis of nucleic acids in leukemia affected cells in the bone marrow and acting mainly in the S-phase of cell division process in cancerous cells and alloHSCT therapy use to combined targeted therapy and cure to certain types of acute myeloid leukemia which is create by TP53 mutations.The TPMT and NUDT15 genes evaluated their association with 6MP dose intensity and identified 5 and 6 coding variant in TPMT and NUDT15 respectively.