Abstract
Comments1 September 1976Reset Osmostat in HyponatremiaMICHAEL F. MICHELIS, M.D., F.A.C.P.MICHAEL F. MICHELIS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-403_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper by DeFronzo, Goldberg, and Agus, "Normal Diluting Capacity in Hyponatremic Patients" (Ann Intern Med 84:538-542, 1976), proposes three criteria for the diagnosis of reset osmostat in patients with hyponatremia: a normal response to water loading, concentration of the urine when serum tonicity is raised above the reset level, and failure to correct the hyponatremia with salt loading.I wish to take issue with the last of these proposed criteria. One of the points emphasized in a recent report (1), cited by DeFronzo and associates, was that reset phenomena could be demonstrated in a patient with...Reference Reference1. MICHELISFUSCOBRADGON MRR: Reset of osmore-ceptors in association with normovolemic hyponatremia. Am J Med Sci 267:267-273, 1974 CrossrefMedlineGoogle Scholar1. DUNNBRENNANNELSON FTA: The role of blood osmolality and volume in regulating vasopressin secretion in the rat. J Clin Invest 52:3212-3219, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nephrology Section Department of Medicine Lenox Hill Hospital New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1976Volume 85, Issue 3Page: 403-404KeywordsAttentionHyponatremiaSaltsUrine Issue Published: 1 September 1976 PDF DownloadLoading ...
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