Abstract
Background: Economically-poultry-significant avian viruses can also provide scientific insights in un-experimentable human topics. Virological studies in poultry reflect natural phenomena, as they replicate in commercial flocks, causing natural infections, natural stress, large populations, allowing rare events understanding. This presentation will review long-term studies on oncogenic viruses (1) and on circovirus infections (2) elaborating on human infections with similar virus-families.1.Davidson,I. & Silva,R.F. (2008). Virus Genes 36: 1-10.2.Davidson,I. & Shulman, L. M. (2008). Virus Research 137: 1-15. Methods: Molecular integration were assessed by the detection of chimeric molecules in vivo. Results: Avian tumor viruses include one herpes- and four retroviruses. Molecular recombination between DNA and retroviruses was created in vitro, resulting in an recombinant MDV with altered properties (Drs. Kung and Witter, USA). We now questioned multiple-virus-infections in commercial flocks, examining whether interviral molecular recombinations occur also in vivo, and found 25% double-virusinfected commercial flocks and 5% samples with molecular integrations. Spontaneous interviral recombination occurred also between retroviruses in commercial birds, emerging in the avian leukosis-subgroup-J, that caused great economic losses. Avian tumor viruses could provide animal models to human dual infections with herpesviruses and retroviruses. We also reviewed similarities between human Anellovirus and avian Circoviridae, to examine whether knowledge acquired from studies of natural and experimental avian infections with could reflect on human Anelloviruses. Conclusion: Studies on avian circoviruses, specifically chicken anemia virus (CAV) can add to current understandings on Anellovirus infections, directed towards finding associated diseases. The health burden imposed by Circoviridae and Anellovirus infections may be underestimated because lack of awareness for search beyond the predominant clinical effects of identified pathogens. Their immunomodulatory contribution by co-infecting Circoviridae and, by analogy, human Anelloviruses necessitates consideration. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive
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