Abstract

Lessons from the Study of Covalent Dimers of the Alzheimer’s Disease-Associate Amyloid β-Protein

Highlights

  • In nature, there are only two reactions that could yield covalent Aβ dimers

  • One mechanism involves the phenolic coupling of tyrosine residues

  • of Aβ can also be achieved by the enzyme catalyzed formation of isopeptide bonds

Read more

Summary

Introduction

There are only two reactions that could yield covalent Aβ dimers. One mechanism involves the phenolic coupling of tyrosine residues and the other the formation of an isopeptide bond between Gln15 and Lys16 (Figure 1).

Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call