Abstract
Lessons from the Study of Covalent Dimers of the Alzheimer’s Disease-Associate Amyloid β-Protein
Highlights
In nature, there are only two reactions that could yield covalent Aβ dimers
One mechanism involves the phenolic coupling of tyrosine residues
of Aβ can also be achieved by the enzyme catalyzed formation of isopeptide bonds
Summary
There are only two reactions that could yield covalent Aβ dimers. One mechanism involves the phenolic coupling of tyrosine residues and the other the formation of an isopeptide bond between Gln15 and Lys16 (Figure 1).
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