Abstract
ObjectivesTo evaluate the clinical characteristics and radiological features of solid pseudopapillary tumor (SPT) and assess surgical therapy strategy.MethodsA retrospective review was performed in 62 patients pathologically confirmed of SPT treated between 2003 and 2014. The clinical features, radiological examinations and surgical strategies were analyzed.Results56 females and 6 males were included in this study, mean age was 26 years old (range: 8–66 years old) with mean size of the tumor was 7.2 cm (range: 3–15 cm), and most tumor were commonly located in the head of pancreas (n = 29). Among all the cases, 3 patients had liver metastasis and underwent resection of SPT and liver metastasis. Furthermore, we performed 29 cases of local tumor excision; other patients underwent pancreaticoduodenectomy, middle pancreatectomy, middle pancreatectomy with splenectomy, distal pancreatectomy with spleen preservation, distal pancreatectomy with splenectomy and duodenum-preserving pancreatic head resection. No patient suffered from lymph node metastases. After median follow-up of 46 months (range: 2–135 months), no mortality or local recurrence or distant metastasis was found.ConclusionsSolid pseudopapillary tumor is a latent malignant tumor with excellent prognosis. If feasible, less aggressive resection without regular lymphadenectomy is recommended for treatment of patients with SPT.
Highlights
Less aggressive resection without regular lymphadenectomy is recommended for treatment of patients with Solid pseudopapillary tumor (SPT)
Solid pseudopapillary tumor (SPT) of pancreas is a rare neoplasm that typically occurs in young women, accounting for only 1%–2% of exocrine pancreatic tumors and about 5% of cystic pancreatic tumors [1]
62 cases of SPT treated in our hospital were analyzed retrospectively; attempted to summarize the clinical features, surgical strategies and long-term follow up for a better understanding of its natural history and prognosis
Summary
Solid pseudopapillary tumor (SPT) of pancreas is a rare neoplasm that typically occurs in young women, accounting for only 1%–2% of exocrine pancreatic tumors and about 5% of cystic pancreatic tumors [1]. With the widespread availability of high-quality imaging systems and a better understanding of its pathology, the number of patients diagnosed of SPT increased considerably. This had resulted in a significant change in diagnostic and treatment approaches over the decades. The WHO defines tumors with surrounding tissue invasion, perineural invasion, vascular invasion on microscopic pathology, and metastasis as malignant SPT [5]. 62 cases of SPT treated in our hospital were analyzed retrospectively; attempted to summarize the clinical features, surgical strategies and long-term follow up for a better understanding of its natural history and prognosis
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