Abstract
SummaryIntroduction: The Labé regional hospital is the second largest hospital in Guinea. Our aim was to determine the incidence of transfusion reactions, describe their management and identify the factors associated with their occurrence.Material and methods: This was a cross-sectional descriptive and analytical study conducted over 6 months from 1 November 2019 to 30 April 2020 at Labé regional hospital. We divided transfusion reactions according to WHO grades. We performed a statistical analysis to identify the factors associated with the reactions recorded.Results: Of the 246 patients transfused with whole blood, 14 developed a transfusion reaction, a frequency of 5.7%. For 55.1% of patients, the initial haemoglobin level varied between 5.1 and 8g/dl, and severe malaria was the most frequent indication for transfusion (28.0%). Of the 14 patients who developed a transfusion reaction, 8 (57.1%) were women. Shivering-hyperthermia syndrome was the most common transfusion reaction with 57.1% (n=8). All transfusion reactions were grade 1 and occurred during transfusion (50% within the first 30 minutes). The mean duration was 52.28 minutes. The management measures were based on stopping the transfusion (85.7%), maintaining the venous line (85.7%), administering an anti-inflammatory drug (85.7%) and stopping the transfusion (85.7%), maintenance of the venous line (85.7%), administration of medication and monitoring of vital parameters (100%).The drugs administered were dexamethasone and calcium gluconate (100%), paracetamol (78.6%) and metopimazine (7.1%). Transfusion history was significant, but no deaths were recorded.Conclusion: Transfusion reactions are not negligible at Labé Regional Hospital.Subsequent studies to assess the knowledge of healthcare staff and strengthen their ability to carry out good transfusion practice would help to reduce this frequency and improve the transfusion safety of patients at Labé Regional Hospital. Keywords: Transfusion reactions, Therapeutic attitude, Labé regional hospital, Guinea
Published Version
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