Abstract
Horse race as well as human dope testing are currently progressing and detection capabilities of laboratories must improve accordingly. Biomolecules such as Erythropoietin and Growth Hormone are up to date doping agents which break the integrity of racing and welfare of horses. New improvements of mass spectrometry allow detection of small concentrations of these peptides. Qualitative determinations can be performed when the structure of the hormone administered can be distinguished from the natural form. Selected indirect markers can also be used to detect abuse of growth hormone: these markers can be insulin growth factors (mainly IGF-1), binding proteins (IGFBP-3) and some bone markers such as osteocalcin. Encouraging results are already obtained but it is necessary to support and to encourage fundamental and applied research to maintain dope testing at the highest level.
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