Abstract
Aspirin-induced asthma is classically severe and aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit COX-1 may be dangerous. Thus, the distinction between aspirin-induced asthma and aspirin-tolerant asthma is a necessity. The association of nasal polyposis (and rhinitis), asthma and aspirin sensitivity described by Widal in 1922 is still valid. A prior asthmatic reaction associated with aspirin or NSAIDs is the best predictor of aspirin-induced asthma. However, among asthmatic patients and in particular those suffering from severe disease, the diagnosis is difficult to predict without aspirin provocation test.
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