Lercanidipine-associated nocturia

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Sir, A 64-year-old man had longstanding essential hypertension without target organ damage and mild benign prostatic hypertrophy treated with alfuzocin 2.5 mg qd and associated with nocturia once a night. He was otherwise healthy and blood pressure was well controlled (125/80 mmHg) by long-term treatment with enalapril (20 mg bid), losartan 50 mg/hydrochlorothiazide 12.5 mg qd, metoprolol 200 mg qd (morning) and amlodipine 10 mg qd (evening). Significant bilateral pitting ankle edema (+2) developed after several months, and no other cause than amlodipine could be found. There were no signs …