LEPTIN AND ADIPONECTIN PLASMA CONCENTRATION IN OBESE AND OVERWEIGHT PATIENTS

Abstract

In obese patients, Leptin plasma concentration is high. This problem is called “leptin resistance”.In reverse, adiponectin concentration is low in overweight and obese patients with insulin resistance, dyslipidemia. Objectives: 1. To determine the plasma leptin and adiponectin concentration in overweight and obese patients. 2. To evaluate the correlation between plasma leptin concentration with plasma adiponectin, glucose concentration, BMI, and blood pressure in overweight and obese patients. Methods: The study was carried out on 137 people (67 normal individuals and 70 overweight and obese patients). Concentrations of leptin and adiponectin were determined by ELISA (Enzyme Linked Immuno Sorbent Assay). Results and conclusions: concentrations of leptin in control group was 6.75 ± 5.17 ng/ml, overweight group was 8.95 ± 4.98 ng/ml, and obese group was 11.59 ± 5.76 ng/ml. Concentrations of adiponectin in control group were 9.67 ± 5.06 µg/ml, overweight group was 7.81 ± 4.83 µg/ml, and obese group was 5.87 ± 4.1 µg/ml. Concentrations of leptin in overweight and obese patients was higher than control group. Concentrations of adiponectin in overweight and obese patients was lower than control group. There were positive correlation between leptin concentration and BMI, blood pressure, fasting glucose concentration. And there was inverse correlation between leptin concentration and adiponectin concentration. Key words: Leptin, adiponectin, obese, overweight.