Left ventricular long-axis ultrasound strain (GLS) is an ideal indicator for patients with anti-hypertension treatment

Abstract

ABSTRACT Background Primary hypertension is one of the most well-known risk factors for cardiovascular disease. Currently, there is still no ideal indicator for left ventricular end-diastolic pressure. Methods 73 hypertension patients and 37 healthy people were enrolled in this study. Each member was examined with conventional echocardiography including multiple indicators such as Peak mitral valve flow velocity (E, A), E/A, left atrial volume index (LAVl), tissue Doppler (PW-TDI) peak velocities during early and late diastolic mitral valve flow (e ‘), E/e ‘, and GLS. We have collected clinical data from all enrolled members. The above cardiac ultrasound indicators were obtained before the antihypertensive treatment, one month and three months after treatment. Results Left ventricular end-diastolic pressure (LVEDP) was positively correlated and negatively correlated with GLS (r = 0.638, P < .01) and E/e’ (r = −0.578, P < .05), respectively. The hypertensives had lower e’ value and higher values of GLS, E/e’, and LAVI than the control group (P < .05). GLS and E/e’ were significantly lower in hypertension group than those in the Control group after one month and three months of treatment (P < .05). The improvement rate of GLS was significantly higher than those in the improvement rate of e’, E/e’, LAVI after treatment (p < .05). Conclusion The GLS improvement rate was significantly higher than those of e’, E/e’ after one and three-month treatment. Therefore, GLS might be a potential ideal index for patients with anti-hypertension treatment. The results obtained in this study provide useful information for further study.