Abstract
Neurodevelopment![Figure][1] Cross-sectional reconstruction of a C. elegans embryo (teal) showing higher (red) and lower (blue, green, and purple) morphogen concentrations IMAGE: SANDEEP GOPAL/MONASH UNIVERSITY Morphogens of the Wnt family regulate development during embryogenesis in organisms ranging from hydra to humans. These peptides, secreted in globular form by the synthesizing cells, initiate signaling cascades that direct morphogenesis. Wnt protein stability in the extracellular environment depends on its multiple disulfide bonds. Torpe et al. identified the protein-folding chaperone in the small nematode Caenorhabditis elegans that is required for viability of a Wnt variant. By controlling folding of this Wnt variant, the protein disulfide isomerase (PDI) controls neuronal migration. Similarly, human cells tested with a pharmacological inhibitor of PDI confirm that Wnts can regulate human development, too. Cell Reports 10.1016/j.celrep.2019.02.072 (2019). [1]: pending:yes
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