Abstract
Peptic ulcer disease (PUD) is a common problem, it consists in defects in the gastrointestinal mucosa that extend through the muscularis mucosae. Most ulcers occur when the normal mechanisms are disrupted by superimposed processes such as Helicobacter pylori infection and the ingestion of nonsteroidal anti-inflammatory (NSAI) drugs. Since the introduction of proton-pump inhibitors, cyclo-oxygenase-2-selective anti-inflammatory drugs and eradication of Helicobacter pylori infection, the incidence of PUD has decreased. This article reviews the etiology, clinical manifestations, diagnosis and treatment of peptic ulcer.
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