Abstract
BackgroundMicromeria fruticosa (L.) Druce ssp. brachycalyx P. H. Davis and Rhus coriaria L., which are Lamiaceae species, are used both as spices in food and medicinally. Lamiaceae species are known to contain high amounts of polyphenols. In this study, liquid chromatography–quadrupole time-of-flight–tandem mass spectrometry (LC-QTOF-MS/MS) was used for analysis of polyphenols in the plants. Under gradient elution with using 0.1% aqueous acetic acid solution and acetonitrile mobile phases, an Agilent Poroshell C18 reversed phase column was used for the simultaneous determination of 18 polyphenols, and separation was performed in 30 min. Pharmacokinetic properties of these polyphenols such as drug-like and toxicity were estimated using open-source software, pkCSM and SwissADME.ResultsThese compounds were determined to represent different classes of polyphenols, including phenolic acids, flavonoids, coumarin and tannins. ADMET predictions of polyphenols indicated that these compounds are easily absorbed and do not have toxic effects.ConclusionWhile the Rhus coriaria L. includes anthocyanidins, tannins, phenolic acid and flavonoids, the Micromeria fruticosa (L.) Druce ssp. brachycalyx P. H. Davis has phenolic acid, coumarin and flavonoids, according to these results. In silico ADME/Tox predictions revealed that these bioactive components are to be drug-like and non-mutagenic. These data are supportive for future analysis that can lead to their therapeutic use of the plants, suggesting that this species may be used as a natural medicinal source in the future after detailed analysis tests.Graphical abstract
Highlights
Micromeria fruticosa (L.) Druce ssp. brachycalyx P
When looking through the literature, it is clear that the liquid chromatography–mass spectrometry approach is one of the most widely used methods for analysing phenolic chemicals in medicinal plants [9, 10]
Major polyphenolic compounds were analysed by comparing the molecular weights of these compounds and their fragments with the fragments provided by standard compounds and literature information
Summary
Micromeria fruticosa (L.) Druce ssp. brachycalyx P. Under gradient elution with using 0.1% aqueous acetic acid solution and acetonitrile mobile phases, an Agilent Poroshell C18 reversed phase column was used for the simultaneous determination of 18 polyphenols, and separation was performed in 30 min. (M. fruticosa spp. brachycalyx) is grown in South Anatolia. This species is known as “tas nanesi” and has the smell of peppermint due to its essential oil components. (R. coriaria) is grown widely in Africa, South Anatolia, the Mediterranean region and West Asia. It is common in the Mediterranean and South-eastern of Turkey. It is known that phenolic compounds, which constitute the widest class of phytochemical compounds contained in both plants, have various bioactive properties. When looking through the literature, it is clear that the liquid chromatography–mass spectrometry approach is one of the most widely used methods for analysing phenolic chemicals in medicinal plants [9, 10]
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