Abstract
Cytokeratin positive cells are frequently found in the blood (BL) and bone marrow (BM) of patients with epithelial cancers and attributed to metastasis. We document here epithelial cells in normal BL and BM (Lonza) using four different methods: immunofluorescence microscopy (IF), Krt1-14CreERT;mTmG transgenic mice, NanoString Gene Expression Assays, and flow cytometry. We have made several novel findings. First, we observed rare but reproducible pan-cytokeratin immunoreactive cells (Dako) in untreated human and murine BL and BM.
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