Abstract
Ambient particulate matter (PM) is a major contributor to environmental air pollution-associated skin damage. However, most published studies are observational or epidemiologic and have not mechanistically investigated the combined effects of air pollutants on cellular senescence and aging, particularly in combination with Ultraviolet (UV) radiation. Herein, we analyzed whether UVA aggravated PM induced inflammatory cascade, which contributes to aging of skin-derived cells. We hypothesized that the cell senescence is involved PM&UVA-induced aging and tested whether an L-ascorbic acid compound, containing vitamin E and ferulic acid, can inhibit PM&UVA-induced aging.
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