Abstract
Seed husk of Plantago ovata (ispaghula) is a popular laxative used to regulate bowel movements. It is generally believed that its laxative effect is mediated through its fibre and/or hydrophilic mucilloid contents. We demonstrate in this communication that it also contains active chemicals causing a laxative effect. An aqueous–methanol extract of ispaghula at a dose range of 1–10 mg/mL caused a dose-dependent stimulatory effect in guinea-pig ileum. Pretreatment of tissue with atropine (1 μM) completely blocked the contractile effect of a supra-maximal dose of acetylcholine (10 μM) similar to that of the lower doses of ispaghula (1–4 mg/mL), however, the effect of the larger doses (6 and 10 mg/mL) was blocked partially. These results indicate that the stimulatory effect of ispaghula at lower doses is mediated through an ACh-like mechanism and the effect of high doses was mediated partially through unknown mechanism(s). © 1998 John Wiley & Sons, Ltd.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call