Latest Research Progress of Ovary Granulosa Cell Tumors

Abstract

Ovarian granulosa cell tumor(GCT) , a group of low grade and potential recurrence functional tumor, with the adult GCT (AGCT) and juvenile GCT(JGCT) . Ovarian GCT is one of the ovarial sex cord stromal tumors, accounting for 2%-5% of ovarial tumors. Etiology of GCT is still unclear. The most common symptom of GCT patients was menstrual disorder or abnormal vaginal bleeding. Surgery is the mainstay of initial management for patients with a suspected GCT. Ovarian GCT are characterized with recurrence. Stages of GCT are always indicative to be prognosis factors. Inhibin and anti-Mullerian hormone (AMH) were reported to have a certain value for diagnosis and follow-up of GCT. A single recurrent somatic mutation of forkhead transcription factor (FOXL) 2 gene c. 402C→G in whole transcriptome sequencing of FOXL2 gene in AGCT. While the mutation were absent in JGCT patients. To date, its biological role of this mutation is yet unclear. In summary, patients with early stage of GCT have an excellent prognosis. Recurrence of GCT is associated with a poor prognosis. For its long-term recurrence, long-term follow-up is needed. Key words: Granulosa cell neoplasm; Forkhead transcription factor 2 gene; Mutation; Inhibin A, B; Anti-Mullerian hormone