Abstract
This study demonstrated, in seven guinea pigs, intact self-stimulation in the lateral hypothalamus after (a) ipsilateral removal of the telencephalon plus (b) transection of the diencephalic and mesencephalic interhemispheric connections down to the brachium conjunctivum. We conclude that ipsilaterally descending fibers suffice to mediate or convey the reinforcing effects of lateral hypothalamic stimulation. The normal extinction that followed withholding of reinforcement indicated a functional interaction between the two hemispheres via surviving brain-stem connections.
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