Abstract
Phase diagrams on ternary and quaternary lipid mixtures showing the existence of liquid-disordered (ld), liquid-ordered (lo) and a mixed phase (ld+lo) are now well established. Although the ld+lo is generally accepted for binary mixtures of cholesterol and phospholipids with saturated acyl chains, the existence of a phase separation in mixtures of cholesterol with phospholipids that have one saturated and one unsaturated acyl chain is not universally accepted. There are reports of a phase diagram on the mixtures POPC/Chol and POPC/Erg and nystatin activity co-related to this purported phase diagram; with a maximal activity appearing in the mixed phase.
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