Latent Space Learning and Feature Learning using Multi-template for Multi-classification of Alzheimer's Disease.

Abstract

Alzheimer's disease (AD) is a common brain disease in the elderly that leads to thinking, memory, and behavior disorders. As the population ages, the proportion of AD patients is also increasing. Accordingly, computer-aided diagnosis of AD attracts more and more attention recently. In this paper, we propose a novel model combining latent space learning and feature learning using features extracted from multiple templates for AD multi-classification. Specifically, latent space learning is employed to obtain the inter-relationship between multiple templates, and feature learning is performed to explore the intrinsic relation in feature space. Finally, the most discriminative features are selected to boost the multi-classification performance. Our proposed model uses the data from the Alzheimer's disease neuroimaging initiative dataset. Furthermore, a series of comparative experiments indicate that our proposed model is quite competitive.