Abstract
<b>Introduction:</b> Pertussis is a highly contagious bacterial respiratory infection affecting all ages. It remains under-recognized in the older adult population despite frequent complications. <b>Aims and objectives:</b> Estimate healthcare resource utilization (HCRU) and direct medical costs (DMC) per pertussis case, among adults ≥50 years of age (YOA) in England. <b>Methods:</b> A retrospective observational study merged data from the Clinical Practice Research Datalink GOLD, Aurum, and linked Hospital Episode Statistics datasets. Adults ≥50 YOA with a pertussis diagnosis from 2009–2018 were propensity score-matched to those without pertussis. HCRU (primary and secondary care) and DMC were estimated for multiple time periods around diagnosis (index). <b>Results:</b> Baseline characteristics and DMC were generally balanced between cases (N=1480) and controls (N=1480). HCRU was significantly higher in the pertussis cohort across all primary care and most secondary care categories 1 month prior to 11 months post index date (p<0.001; Figure). HCRU was highest in the month prior to index across categories. Increases were already observed at 6 to 1 months before index. The pertussis cohort had significantly higher adjusted mean annualized cost per case (+26.7%; 95% CI 15.9-38.5; p<0.001). <b>Conclusion:</b> Pertussis in adults ≥50 YOA significantly increases HCRU and DMC starting before diagnosis, highlighting the need for prevention.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call