Abstract
The purpose of this study was to assess the vasoconstrictor effect of the prostaglandin F2 alpha analog latanoprost in isolated porcine ciliary arteries. With a myograph system to measure isometric forces, porcine ciliary arteries were exposed, in a cumulative manner, to increasing concentrations of latanoprost (0.1 nM-0.1 mM). Experiments were conducted in quiescent vessels as well as in vessels precontracted with potassium chloride (KCl; 40 mM) or endothelin-1 (10 nM). Contractions were expressed in percent of 100 mM KCl-induced contraction. In a concentration dependent manner latanoprost induced significant (p < 0.001) contractions in quiescent vessels (maximum: 68 +/- 3%, n = 5; PD50: 5.7 +/- 0.1). In KCl or in endothelin-1 precontracted vessels latanoprost did not evoke any relaxation but in contrast significant (p < 0.001) contractions (maximum: 33 +/- 4%, n = 5 and 26 +/- 6%, n = 8, respectively). Latanoprost has a vasoconstrictor effect in isolated porcine ciliary arteries. No relaxation could be observed. The clinical relevance of this finding requires further evaluation.
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