Laser beam resonant interaction of new hydantoin derivatives droplets for possible biomedical applications

Abstract

This paper deals with the rapid molecular changes induced by laser radiation on two novel hydantoin derivatives, generically named SZ-2 and SZ-7, having promising pharmaceutical properties as Szymanska et al. in 2002 and Subtelna et al. in 2010 have reported. Hydantoins solutions with concentration of 10−3M in dimethyl sulfoxide were exposed both in droplets and bulk samples to coherent radiation emitted at 266nm as the fourth harmonic of a Nd:YAG laser during different time intervals. The influence of exposure to laser radiation was highlighted by laser induced fluorescence. Also, dynamic wetting (in terms of surface tension and contact angle) measurements were performed in order to find information valuable for further development and modification of hydantoins. All these studies intend to provide physical data in order to better understand the behavior and the activity of this kind of potential drugs on biological targets. Experimental results prove that the investigated molecules are photoreactive. Changes produced in a pendant microdroplet are orders of magnitude faster than in the case of bulk exposure.The surface tension values of unirradiated/irradiated hydantoin derivatives solutions in dimethyl sulfoxide are stable along the time interval of measurements, indicating that the molecules are evenly distributed in drop solution and they are not adsorbed at air–liquid interface. However, a very low gradient of dynamic surface tension values of the unirradiated samples, and the irradiated ones is registered for the SZ-2 compound. This suggests the modification of the cohesive strength of the molecules inside the droplets exposed to laser radiation.The contact angles equilibrium values of droplets on hydrophobic surface show no remarkable differences for unirradiated/irradiated imidazolidines samples, though the small increase of the contact angle for irradiated SZ-7 confers it a more hydrophobic property.