Large trial compares lansoprazole to omeprazole

Abstract

Q LARGE TRIAL COMPARES LANSOPRAZOLE TO OMEPRAZOLE DO Castell, JE Richter, M Robinson, S Sontag. The Graduate Hospital, Philadelphia, PA; University of Alabama, Birmingham, AL; Oklahoma Foundation for Digestive Research, Oklahoma City, OK; Hines VA Hospital, Hines, IL. Lansoprazole (LAN) 30 mg and l5 mg QD were compared to omeprazole (OME) 20 mg QD and placebo (PBO) in patients with endoscopically proven erosive reflux esophagitis (RE) in a randomized, double-blind, multicenter clinical trial. Forty-four (44) investigators enrolled 1284 patients (836 males/448 females): LAN 30 rag: 422 patients, LAN 15 mg: 218 patients, OME 20 rag: 431 patients, PBO: 213 patients. Study medication was taken each day for eight weeks. Endoscopies were performed at baseline, weeks 2, 4 and 8 (and week 6 if not healed at week 2 and week 4). Results: LAN 30 mg was as effective as r~nt~ e of Ni hts with a e ~ m OME 20 mg and both were more effective ~w,,.~L ~,~,,,o~ (p 2% occurrence) were headache, diarrhea, and nausea. As expected, fasting serum gastrin levels increased significantly from baseline in all active-treatment groups; however, median fasting serum gastrin levels remained within normal limits for all treatment groups. Conclusion: LAN 30 mg QD provided faster heartburn reliefthan OME 20 mg QD and is as safe and effective as OME 20 mg QD in healing erosive RE. This research was funded by TAP Pharmaceuticals Inc., Deerfield, IL. • HP POSITIVE FUNCTIONAL DYSPEPSIA IN ELDERLY PATIENTS: COMPARISON OF TWO TREATMENTS. F. catalano, °R. Terranova, A. Brogna, G. Branciforte, R. Catanzaro, A. Liberti, C. Bentivegna, *S. Luca. Dept of Internal Medicine. Gastroenterology Unit. *Geriatric Dept. University of Catania. Italy.