Intravenous lansoprazole in treating duodenal ulcer bleeding:a multi-center clinical trial

Abstract

Objective To assess the efficacy and safety of intravenous infusion of lansoprazole in treating duodenal ulcer bleeding.Methods A multi-center,randomized,parallel-controlled,and positive-drug contrast clinical trial was conducted in 216 patients with endoscopic proved duodenal ulcer bleeding.The patients were randomly divided into lansoprazole group(n=110)and control group (n=106).Patients in lansoprazole group were intravenously received lansoprazole(Allwell)of 30 mg twice daily for 5 days,while those in control group were intravenously received omeprazole sodium (Losee)of 40 mg twice daily for 5 days.Results There were 212 cases qualified for analysis of efficacy and safety.The effective rate and response rate were 73.39 0A and 95.41%in lansoprazole group respectively,while they were 81.55%and 95.15%in control group,respectively(P＞0.05).Haemostatic time and haemostatic rate were(31.90±18.58)h and 98.17%in lansoprazole group respectively,while they were(28.00±18.31)h and 99.03%in control group,respectively(P＞0.05).The major adverse events were leucopenia,slight elevated transaminase and rach(P＞0.05).Conclusion Intravenous lansoprazole is a safe and effective drug for treatment of duodenal ulcer bleeding. Key words: Duodenal ulcer; Bleeding; Lansoprazole