Abstract
Clathrin-coated structures must assemble on cell membranes to internalize receptors. These structures can grow surprisingly large, containing over 20 clathrin seemingly locked in a hexagonal lattice, yet often fail to form productive vesicles. We show that these abortive events happen spontaneously when adaptor availability is low, despite abundant clathrin. Here, we combine recent in vitro kinetic measurements with stochastic reaction-diffusion simulations and theory to differentiate mechanisms of stable vs unstable clathrin assembly on membranes.
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