Abstract
A report on the genomics workshop 'Identification of Functional Elements in Mammalian Genomes', Cold Spring Harbor, New York, 11-13 November 2004.
Highlights
Computational and experimental genomics researchers convened at Cold Spring Harbor Laboratory at the end of 2004 to address the ambitious goal of identifying all the functional elements in the human genome
The functional elements discussed at the meeting included protein-coding genes, regulatory elements, RNA genes and DNA sequences that dictate chromosome structure or replication
The meeting followed a gathering of the ENCODE consortium, which aims to identify a comprehensive ‘Encyclopedia of DNA elements’ in the human genome [http:// www.genome.gov/10005107]
Summary
Large-scale discovery and validation of functional elements in the human genome Bradley E Bernstein*† and Manolis Kellis*‡. Computational and experimental genomics researchers convened at Cold Spring Harbor Laboratory at the end of 2004 to address the ambitious goal of identifying all the functional elements in the human genome. Participating laboratories are developing computational techniques for sequence assembly, gene identification and regulatory motif discovery, as well as experimental methods for identifying transcripts, chromatin structures and regulatory regions. Against this backdrop, most speakers described experimental and computational approaches that generated vast numbers of candidate functional elements, from comprehensive transcript catalogs to lists of highly conserved sequence elements. They were complemented by a smaller number of presentations dealing with the daunting task of systematically validating these elements
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