Abstract
Publisher Summary This chapter reviews large granular lymphocytes (LGL) as effector cells of natural killer (NK) activity in the mouse. The possibility of identifying the effector cells of NK cytotoxicity by their morphology is a relatively new acquisition. In a study described in the chapter, the possible relationship between LGL and mouse NK activity was investigated. Two main approaches were used: (1) the distribution of LGL in different lymphoid and nonlymphoid organs was studied with a focus on mouse peripheral blood in analogy with the human studies and (2) this study also investigated the hypothesis that the large lymphocytes with cytoplasmatic granules, which are known to be present in high proportions in the epithelium of the small intestine of mammals, might exert NK activity at that site. This chapter summarizes the results obtained, indicating that LGL are also effector cells of NK activity in mice. Several lines of evidence suggest that NK cells are a heterogeneous population. The serological characterization of the NK effector cells in the mouse small intestine, where the cytotoxicity is mainly exerted by LGL, revealed strong similarities between these cells and the NK T subset.
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