Abstract
BackgroundLysosomal protein transmembrane 4 beta (LAPTM4B) is a gene related to hepatocellular carcinoma that has two alleles designated LAPTM4B*1 and LAPTM4B*2. This study aimed to investigate the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who have undergone resection for hepatocellular carcinoma (HCC).Methodology/Principal FindingsThe LAPTM4B genotype was analyzed by PCR in 68 patients who had undergone curative hepatic resection for hepatocellular carcinoma. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan–Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P<0.001). Multivariate analysis showed that LAPTM4B genotype is an independent prognostic factor for OS and DFS (both P<0.001).Conclusions/SignificanceAllele *2 of LAPTM4B is a risk factor associated with poor prognosis in patients with resected HCC. LAPTM4B status may be useful preoperatively as an adjunct in evaluation of the operability of HCC.
Highlights
Hepatocellular carcinoma (HCC) is the third most common cause of cancer death in the world and is the most common cause of cancer death in China [1,2,3,4]
We found that genotype *2 of the Lysosomal protein transmembrane 4 beta (LAPTM4B) gene was significantly associated with recurrence, poor histopathologic differentiation, higher TNM stage and portal vein invasion (Table 1; P,0.05), but not with viral infection status, tumor size or serum AFP level, age or gender (Table 1; P.0.05)
We tested LAPTM4B genotype by PCR assay in 68 patients who had surgical resection for hepatocellular carcinoma
Summary
Hepatocellular carcinoma (HCC) is the third most common cause of cancer death in the world and is the most common cause of cancer death in China [1,2,3,4]. Knockdown of LAPTM4B by RNA interference reverses multiple malignant phenotypes [16] These observations and data argue that this gene plays a fundamental role in many types of neoplasia, and previous studies have shown that LAPTM4B protein is overexpressed in HCC, and this overexpression is significantly correlated with tumor histopathological grade and prognosis. This has led us to consider whether it could serve as a prognostic marker in patients under evaluation for resection of HCC. This study aimed to investigate the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who have undergone resection for hepatocellular carcinoma (HCC)
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