Laparoscopic gastric sleeve resection for metabolic syndrome (MS) with obstructive sleep apnea-hypopnea syndrome (OSAHS): Report of two cases

Abstract

To evaluate the therapeutic efficacy of Laparoscopic Gastric Sleeve Resection (LGSR) for patients with metabolic syndrome and Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). Two patients with metabolic syndrome and OSAHS received LGSR in our hospital in 2015 and were postoperatively followed up for 3 months to observe relief of the symptoms of Acanthosis Nigricans (AN) and snoring, and changes in metabolism-associated parameters, endocrine hormones and inflammatory factors. The results of 3-month postoperative follow-up observations showed that body weight was reduced and the associated symptoms of AN and snoring were relieved significantly in both patients. Body Mass Index (BMI) and neck and abdominal circumferences were also decreased significantly. Metabolism-related biochemical parameters, inflammatory factors and endocrine hormones including Apnea-Hypopnea Index (AHI), Red Blood Cell Distribution Width (RDW), Fast Blood Glucose (FBG), blood insulin, CReactive Protein (CRP), mean blood pressure and sex hormones all underwent favorable changes in both patients. The clinical outcome of the two patients in our series demonstrates that LGSR is a viable option for the treatment of patients with metabolic syndrome and OSAHS in that it can relieve the snoring symptoms of sleep apnea, improve lipid and glucose metabolisms and endocrine hormone levels in obese patients, and attenuate their chronic inflammation. Keywords: laparoscopic gastric sleeve resection; obstructive sleep apnea-hypopnea syndrome (OSAHS); inflammation; sex hormone.