LACTOFERRIN – A ROLE IN THE PROTECTIVE FUNCTIONS IN ADOLESCENTS WITH LATENT TUBERCULOSIS INFECTION

Abstract

When evaluating the role of lactoferrin to improve the effectiveness of preventive treatment of latent tuberculosis infection in adolescents, it was found that the prescriptions of Lactoferrin imun + Colostrum contributed to a significantly more pronounced decrease in the frequency of hyperergic reactions in test with tuberculosis recombinant allergen (from 51.3% to 12.5% in the main group, from 50.7 % to 33.3% in the comparison group, p < 0.05), a decrease in the average size of the papule (from 17.6 mm to 8.2 mm in the main group and from 17.1 to 14.5 mm in the comparison group, p < 0.05). In patients of the main group, the restoration of free radical oxidation and antioxidant protection indicators to the level of healthy donors was established, while in the comparison group, the intensity of blood plasma chemiluminescence and the activity of myeloperoxidase in neutrophils remained elevated, while the activity of catalase and superoxidedismutase remained reduced. The level of lactoferrin during treatment in the main group increased to normal values (740 ng/ml, 95%CI 702.2-777.8), and in the control group remained reduced (440 ng/ml, 95%CI 411.5-478.5), p < 0.05. At the same time, the continuing level of positive reactions to tuberculosis recombinant allergen (Diaskintest®) against the background of normalization of the lactoferrin level indicates the high diagnostic capabilities of Diaskintest® to detect LTBI in adolescents