Abstract
본 연구는 여성의 손으로부터 분리한 두 유산균의 co-culture에 의한 향장활성에 대한 것이다. Lactobacillus rhamnosus (L. rhamnosus)와 Lactobacillus paracasei (L. paracasei)를 함께 배양하는 것은 최초이며, co-culture를 이용한 유산균은 tyrosinase 저해율이 L. paracasei와 L. rhamnosus에 비해 20.68%로 가장 높은 수치를 보였다. 또한, co-culture 유산균은 melanin 생성 저해율에서도 63.5%의 가장 높은 활성을 보였으며, 주름개선활성에 영향을 미치는 MMP-1의 생성량이 3726.3 pg/mL로 확인되었다. 반면 단일 유산균 배양시 얻어지는 MMP-1 생성량은 각각 L. rhamnosus가 13613.5 pg/mL, L. paracasei는 13012.0 pg/mL이 확인되었다. Collagen 생성량을 확인한 결과 co-culture 유산균이 380.7 ng/mL로 323.4 ng/mL의 양이 확인된 L. paracasei와 304.1 ng/mL의 양이 확인된 L. rhamnosus보다 많은 양이 생성됨을 확인하였다. 상기의 결과는 유산균의 co-culture가 향장활성 증진을 시킬 수 있다는 것을 나타내고, 이는 향장 활성에 영향을 미치는 항산화 활성을 측정한 결과 단일 유산균 배양을 통한 결과보다 co-culture 유산균의 항산화 활성이 더 높은 것으로 확인할 수 있었다. In this study, cosmeceutical activities of the co-cultures of both lactic acid bacteria isolated from the hands of women, Lactobacillus rhamnosus (L. rhamnosus) and Lactobacillus paracasei (L. paracasei) were first reported: For whitening and anti-wrinkle activities, the co-culture showed the highest tyrosinase inhibition of 20.68%, compared L. paracasei and L. rhamnosus. The co-culture also showed the highest inhibition of melanin synthesis as 63.7%. In observing the anti-wrinkle activities of the co-culture, it generated only 3726.3 pg/mL of matrixmetalloproteinase-1 (MMP-1) production when 13613.5 pg/mL and 13012.0 pg/mL of MMP-1 production were estimated from L. rhamnosus and L. paracasei. Besides these, the extract from the co-culture yielded higher collagen production as 380.7 ng/mL, compared to 323.4 ng/mL and 304.1 ng/mL from L. paracasei and L. rhamnosus. These results indicate that the co-culture of both lactic acid could improve its cosmetic activities. This hypothesis was also confirmed that the co-culture of both bacteria showed strong antioxidant activities of DPPH free radical scavenging while the extract of L. rhamnosus and L. paracasei.
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More From: Journal of the Society of Cosmetic Scientists of Korea
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