Lack of pharmacokinetic interaction between lincomycin and aspirin in healthy goats

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Lincomycin is a bacteriostatic lincosamide antibiotic activeprimarily against Gram-positive cocci (i.e. staphylococci, pneu-mococci, and unclassifiable streptococci) and against mostanaerobes including Bacteroides fragilis (Pechere, 1986). Thepharmacokinetics of lincomycin has been determined in humans(Fass, 1981) and for a variety of animals including calves(Burrows et al., 1983), dogs (Brown et al., 1975), pigs (Chaleva& Nguyen, 1987), and chickens (Soback et al., 1987). Lincomy-cin is extensively metabolized in liver into N-desmethyl linco-mycin, and lincomycin sulfoxide and approximately 40% of theadministered dose is excreted in the urine as unchangedlincomycin and N-desmethyl lincomycin in pigs (Hornish et al.,1987).In veterinary medicine, the use of nonsteroidal anti-inflam-matory drugs (NSAIDs) such as flunixin or acetylsalicylic acid(aspirin) is often associated with the treatment of coliformmastitis (Ziv, 1992), pneumonia (Balmer et al., 1997), andneonatal septicemia (Baggot, 1994). For practical purposes,single doses of these NSAIDs are frequently used at the initiationof a therapeutic regimen. Salicylic acid is predominantlyeliminated by competing hepatic conjugative and its metabolitesalicyluric acid is secreted mainly into the urine (Needs & Brooks,1985; Minors, 1989). Because of the communal route ofexcretion, drug interaction between lincomycin and aspirinis theoretically possible. Consequently the purpose of thisstudy was to evaluate whether such an interaction exists,and to assess the effect of aspirin on the disposition kinetics andurine concentrations of lincomycin in goats after i.v. or i.m.administration.Ten native-breed nonlactating goats; 2–3 years old andweighing 30–38 kg, were used. Goats were nonpregnant andconsidered clinically healthy, based on history, physical, andclinical examination. The study was reviewed and approved bythe Institutional Animal Care and Use Committee at faculty ofVeterinary Medicine, Cairo University. The animals were ran-domly divided into two groups of five goats each. Animals in thefirst group received a single dose of 20 mg/kg body weight (BW)of lincomycin hydrochloride (Lincocin , Upjohn, Puurs, Bel-gium) i.v. through the left jugular vein. Those in the secondgroup were injected with lincomycin at the same dose i.m. intothe left gluteal muscles. After 1 month washout period, each of2the 10 animals was given aspirin (Aspegic , Le Plessis Robison,France, vials containing 200 mg/mL