Abstract
Effects of clofibrate treatment of 7 days duration were studied on hepatic HMG-CoA (β-hydroxy-β-methylglutaryl Coenzyme A) reductase (EC 1.1.1.34) activity and on acetate incorporation into cholesterol by tissue slices from liver and ileum in 29 young male mash-fed swine in the postabsorptive state. Swine treated with either 2 or 10 gm of clofibrate daily showed marked reductions in serum cholesterol levels. Unlike the large decrease observed in rats, hepatic HMG-CoA reductase activity was not significantly reduced in either treated group. Acetate incorporation into cholesterol by liver and ileal slices was similarly unaffected by clofibrate. These results and our previous cholesterol balance studies of clofibrate-treated swine suggest that the drug does not inhibit cholesterol synthesis in these animals. The mechanism of action of clofibrate in swine may be different from that in rats.
Published Version
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