LACK OF CORRELATION BETWEEN THREE INDICES OF ARTERIAL STIFFNESS IN YOUNG HYPERTENSIVE MEN: PP.10.417

Abstract

Objective: To reveal correlation between three methods of arterial stiffness evaluation in young hypertensive men. Methods: Arterial stiffness was assessed in three groups of young men (18–25 years, mean age 20,9 ± 2,0 years) matching by height and weight: 74 with sustained arterial hypertension (AH), 45 with non-sustained AH, and 15 normotensive subjects. BP status was confirmed with repeated clinic measurement and ambulatory BP monitoring (ABPM). Carotid stiffness index (CS) was assessed as ratio of diastolic and systolic diameter difference and diastolic diameter of common carotid artery (Vivid 7, GE). Aortic pulse wave velocity (PWV) was measured between carotid and femoral artery with Sphygmocor device (AtCor, Australia). Ambulatory arterial stiffness index (AASI) was assessed on ABPM. Spearman's Rank Correlation test was done to evaluate correlation between the three methods of arterial stiffness measurements. Results: In normotensive subjects PWV was 8,6 ± 1,5 m/s, AASI 0,43 ± 0,14, CS 15,8 ± 2,5%. In those with non–sustained AH 8,3 ± 1,2 m/s, 0,47 ± 0,15, 16,0 ± 3,5%, respectively, and in subjects with sustained AH 9,2 ± 1,2 m/s, 0,51 ± 0,16, 14,4 ± 4,6%. Significant correlation was found between CS and AASI r = 0,26, p = 0,006 in all subjects. This correlation was stronger in subjects with sustained AH (r = 0,41, p = 0,0009). Conclusion: The obvious trend for lower arterial elasticity indices was found in young hypertensive men. No correlation between PWV as “gold standard” measure of arterial stiffness and other proposed arterial stiffness indices was found.