Lack of association between miR-218 rs11134527 A&amp;gt;G and Kawasaki disease susceptibility

Lei Pi,Yufen Xu,Di Che,Xijing Huang,Qiulian Deng,Xiaoqiong Gu,Lanyan Fu,Meiai Li,Ping Huang,Li Zhang

doi:10.1042/bsr20180367

Abstract

Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least 5 days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is associated with susceptibility to various cancer risks. However, there is a lack of evidence regarding the relationship between this polymorphism and KD risk. The present study explored the correlation between the miR-218 rs11134527 A>G polymorphism and the risk of KD. We recruited 532 patients with KD and 623 controls to genotype the miR-218 rs11134527 A>G polymorphism with a TaqMan allelic discrimination assay. Our results illustrated that the miR-218 rs11134527 A>G polymorphism was not associated with KD risk. In an analysis stratified by age, sex, and coronary artery lesions, we found only that the risk of KD was significantly decreased for children older than 5 years (GG vs. AA/AG: adjusted OR = 0.26, 95% CI = 0.07–0.94, P=0.041). The present study demonstrated that the miR-218 rs1113452 A>G polymorphism may have an age-related relationship with KD susceptibility that has not previously been revealed.

Highlights

Kawasaki disease (KD) is an acute, systemic inflammatory vasculitis disease that is known as lymphatic mucosa syndrome and usually affects infants and young children [1,2]
Most previous studies have focused on the associations of KD susceptibility with single nucleotide polymorphisms (SNPs), such as SNPs of ITPKC, GRIN3A, ITPR3, ADAM17, CASP3, TARC/CCL17 etc. [5,6,7,8,9]
The results did not reveal a significant relationship between the miR-218 rs11134527 A>G polymorphism and KD susceptibility in Southern Chinese children

Summary

Introduction

Kawasaki disease (KD) is an acute, systemic inflammatory vasculitis disease that is known as lymphatic mucosa syndrome and usually affects infants and young children [1,2]. The clinical features of the disease mainly manifest as a fever lasting 5 days or longer. Patients should be given adequate treatment with intravenous immunoglobulin (IVIG) in the early stage. Epidemiological studies have demonstrated that the incidence rates of KD are increasing year by year in the areas of Japan, South Korea, and Taiwan [4]. Most previous studies have focused on the associations of KD susceptibility with single nucleotide polymorphisms (SNPs), such as SNPs of ITPKC, GRIN3A, ITPR3, ADAM17, CASP3, TARC/CCL17 etc. The relationships between microRNA polymorphisms and KD susceptibility have not been reported

Methods

Results

Conclusion