The miRNA-608 rs4919510 G>C polymorphism confers reduce coronary injury of Kawasaki disease in a Southern Chinese population.

Yanfei Wang,Zhaoliang Lu,Yufen Xu,Ping Huang,Li Zhang,Qihua Liang,Xiaoqiong Gu,Xiantao Qiu,Lanyan Fu,Yaqian Tan,Di Che,Lei Pi

doi:10.1042/bsr20181660

Yanfei Wang, Zhaoliang Lu + Show 10 more

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https://doi.org/10.1042/bsr20181660

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Journal: Bioscience reports	Publication Date: May 17, 2019
Citations: 3	License type: CC BY 4.0

Affiliation: Guangzhou Medical University

Abstract

Kawasaki disease (KD) is also called mucocutaneous lymph node syndrome and is an acute febrile pediatric disease characterized by systemic vasculitis. KD typically occurs in children 5 years old or younger and occurs more often in males than in females. miRNA-608 has been reported to interact with interleukin-6 and affect innate immunity. The immune-mediated inflammation could induce the occurrence of KD; however, there is no previous research focused on the relationship between miRNA-608 polymorphism and the KD risk. The present study explored the correlation between the miRNA-608 rs4919510 G>C polymorphism and the risk for KD. We recruited 532 patients with KD and 623 controls to genotype the miRNA-608 rs4919510 G>C polymorphism with a TaqMan allelic discrimination assay. Single-locus analysis showed no significant association between miRNA rs4919510 G>C polymorphism and KD susceptibility. However in an analysis stratified by age, gender, and coronary artery lesion (CAL), we found a relationship between the miRNA-608 rs4919510 G>C polymorphism and KD susceptibility. When KD patients were stratified by coronary injury, the CG/CC genotypes of the miRNA-608 rs4919510 G>C polymorphism contributed to a higher occurrence of KD than that was found in the GG genotype patients (adjusted odds ratio = 0.74, 95% CI = 0.56–0.98, P = 0.033). The present study demonstrated that the miRNA-608 rs4919510 G>C polymorphism may have a CAL-related relationship with KD susceptibility that has not been previously revealed.

Highlights

Kawasaki disease (KD) is pediatric systemic vasculitis with the well-known complication of coronary artery aneurysm (CAA), which occurs in infants under the age of 5 [1]
When the KD patients were stratified by coronary injury, the CG/CC genotypes of the miRNA-608 rs4919510 G>C polymorphism contributed to a higher occurrence than that was found in the GG genotype patients
More studies have shown that miRNA polymorphism could affect target genes at the posttranscriptional level by binding to the 3 -UTR of their target genes, affecting the development and prognosis of different cancers [30,31]. miRNA polymorphism could affect diseases, for example, hereditary spastic paraplegia, hypertension, and drug resistance [32]

Summary

Introduction

Kawasaki disease (KD) is pediatric systemic vasculitis with the well-known complication of coronary artery aneurysm (CAA), which occurs in infants under the age of 5 [1]. KD has replaced rheumatic fever as the main cause of acquired heart disease in children, which caused the widespread attention of pediatric clinicians [2]. KD has replaced rheumatic fever and has become the most common form of acquired heart disease in children, the cause of KD remains unknown [3]. KD has the characteristics of a regional epidemic and self-limiting disease, with seasonality and high risk in infants and young children. These characteristics have prompted us to consider that the KD pathogen is a microorganism commonly prevalent in the natural environment and that it can cause asymptomatic infection in most individuals and acquired immunity in adulthood [4]. There is compelling laboratory evidence of autoimmune responses directed against self-epitopes

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