Abstract
Oral lichen planus is a premalignant chronic inflammatory mucosal disorder with unknown etiology. It is a multifactorial disease and in addition to genetic background, infections, stress, drug reactions are suggested as risk factors. Helicobacter pylori which is involved in development of many gastrointestinal lesions may also be implicated in oral lichen planus induction. This is of clear importance for cancer prevention and the present study was performed to determine any association between H. pylori infection and oral lichen planus in southwestern Iran. Anti H. pylori IgG levels were determined in 41 patients and 82 sex-age matched controls. The results showed no association between H. pylori infection and oral lichen planus (51% in patients vs. 66% in control). or any of its clinical presentations.
Highlights
Oral lichen planus (OLP) is a chronic inflammatory disease with a prevalence rate of 0.1 to 4% in different populations (Seoane et al, 2004; Thongprasom et al, 2011)
This is of clear importance for cancer prevention and the present study was performed to determine any association between H. pylori infection and oral lichen planus in southwestern Iran
The results showed no association between H. pylori infection and oral lichen planus (51% in patients vs. 66% in control). or any of its clinical presentations
Summary
Oral lichen planus (OLP) is a chronic inflammatory disease with a prevalence rate of 0.1 to 4% in different populations (Seoane et al, 2004; Thongprasom et al, 2011). OLP usually affects stratified squamous epithelium (Eisen et al, 2005) and causes lesions or plaques on buccal mucosa, tongue, and gingiva (Mollaoglu, 2000). Popular, plaque like, erosive, atrophic and bullous are different clinical presentations of OLP. OLP is a mutlifactorial disease and in addition to genetic background, infections, stress and drug reactions are suggested as risk factor (Seoane et al, 2004; Konidena and Pavani, 2011). Helicobacter pylori (H. pylori) is involved in gastrointestinal lesions but its role in OLP is still suspicious (Attia et al, 2010), this study was designed to find any probable association between H. pylori infection and OLP in southwestern Iran
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