Abstract
The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remain controversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. A comprehensive literature search was conducted up to November 20, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Meta-regression, subgroup analysis, sensitivity analysis and publication bias were also performed. Eight studies involving 1,059 BC cases and 1,061 controls were included. The meta-analysis showed that there was no significant association between the two common mutations of CYP1A1 and BC risk. For the I1e462Val A/G polymorphism with GG vs. AA the OR was 1.47 (95 % CI= 0.70-3.07, P =0.308). For the MspI T/C polymorphism, though a slight trend was found this was not statistically nonsignificant (CC vs.TT, OR = 1.24, 95 % CI= 0.98-1.58, P =0.078). Subgroup analyses by ethnicity also found no obvious association between CYP1A1 and BC risk. The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk.
Highlights
Bladder cancer (BC) remains the second leading malignancy of the genitourinary tract and the seventh most frequently diagnosed cancer in males, accounting for approximately 5.9% (386,300) of the new cancer cases and 3.4% (150,200) of the estimated cancer deaths annually worldwide
We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in bladder cancer (BC)
The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk
Summary
Bladder cancer (BC) remains the second leading malignancy of the genitourinary tract and the seventh most frequently diagnosed cancer in males, accounting for approximately 5.9% (386,300) of the new cancer cases and 3.4% (150,200) of the estimated cancer deaths annually worldwide. One of the most common mutations described is a singlebase exchange from A to G at position 2455 of exon 7, called CYP1A1*2B or m2 (Hayashi et al, 1991) Polymorphism of this heme-binding region causes a substitution of isoleucine with valine in codon 462 (Ile462Val), resulting in an alteration of the functional protein and increasing enzyme activity (Kawajiri et al, 1996). Mutation of this gene exhibits strong potential linkage disequilibrium with another mutation of CYP1A1-MspI (m1) polymorphism (Bartsch et al, 2000), a point mutation (T to C) at the MspI site in the 3’-untranslated region, and has been proven to be associated with increased catalytic activity Such genetic differences in enzymes involved in the biotransformation of environmental risk factors are believed to play a pivotal role in an individual’s susceptibility to environmentally induced cancer and their relationship with various malignancies has been extensively studied (Bartsch et al, 2000). We carried out a meta-analysis to evaluate the association between CYP1A1 polymorphisms and BC risk including all eligible publications to date
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