Abstract
Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.
Highlights
IntroductionThe evolution of antibiotic resistances amongst microorganisms is a global problem [1,2,3]
The evolution of antibiotic resistances amongst microorganisms is a global problem [1,2,3].Because of this, novel antimicrobial substances and synthesis routes are needed
Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains
Summary
The evolution of antibiotic resistances amongst microorganisms is a global problem [1,2,3]. Novel antimicrobial substances and synthesis routes are needed. Enzymatic catalysis may be an alternative to conventional chemical synthesis processes [4,5]. The oxidoreductase laccase [E.C. 1.10.3.2, benzenediol:dioxygen oxidoreductase] possesses a number of advantages. The reactions can be performed under mild and environmentally friendly conditions, such as atmospheric pressure and room temperature. No cofactors such as a coenzyme or NADPH are needed
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